解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2019-318715
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-318281
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The risk of GI bleeding (GIB) in aspirin users after Helicobacter pylori (HP) eradication remains poorly defined. We characterised the incidences and temporal trends of hospitalisations for all GIB in aspirin users after HP eradication therapy. DESIGN:Based on a territory-wide health database, we identified ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-318352
更新日期:2020-03-01 00:00:00
abstract::These consensus guidelines were jointly commissioned by the British Society of Gastroenterology (BSG), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and Public Health England (PHE). They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorecta...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2019-319858
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1-2 years. However, yearly surveillance likely leads to overtreatment for many. We prospectively assessed a surveillance protocol aiming to ...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/gutjnl-2018-318134
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317571
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC. DESIGN:Transcriptional profiling of 273 formalin-fixed paraffin-...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317624
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Chronic pancreatitis (CP) is an inflammatory disease with progressive fibrosis leading to exocrine and endocrine dysfunction. Currently, there are no approved effective therapies for CP. Stimulator of interferon genes (STING) signalling is a key innate immune sensor of DNA. In this study, we evaluated the rol...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317098
更新日期:2019-10-01 00:00:00
abstract::The two major forms of inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions characterised by an increased production of pro-inflammatory cytokines that act as critical drivers of intestinal inflammation. Anti-cytokine therapy has been s...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2019-318448
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis. DESIGN:International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structu...
journal_title:Gut
pub_type: 共识发展会议,杂志文章
doi:10.1136/gutjnl-2019-318556
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:We aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC). DESIGN:Large cohorts of HCA (n=185) and HCC (n=468) were classified using immunohistochemistry. The mutational s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317632
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To present comparative data about the performance of colorectal cancer (CRC) screening programmes in the European Union Member States (EU MSs). DESIGN:Cross-sectional study. We analysed key performance indicators-participation rate, positivity rate (PR), detection rate (DR) and positive predictive value for ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317293
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Patients with gallbladder carcinoma (GBC) lack effective treatment methods largely due to the inadequacy of both molecular characterisation and potential therapeutic targets. We previously uncovered a spectrum of genomic alterations and identified recurrent mutations in the ErbB pathway in GBC. Here, we aime...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-316039
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:To characterise gut microbiome in patients with hepatocellular carcinoma (HCC) and evaluate the potential of microbiome as non-invasive biomarkers for HCC. DESIGN:We collected 486 faecal samples from East China, Central China and Northwest China prospectively and finally 419 samples completed Miseq sequencin...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315084
更新日期:2019-06-01 00:00:00
abstract::Patients with Crohn's disease commonly develop ileal and less commonly colonic strictures, containing various degrees of inflammation and fibrosis. While predominantly inflammatory strictures may benefit from a medical anti-inflammatory treatment, predominantly fibrotic strictures currently require endoscopic balloon ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-318081
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316344
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Chronic HBV infection affects more than 250 million people worldwide and remains a global healthcare problem in part because we lack curative treatment. Sustained viral control requires HBV-specific T cells, but these become functionally impaired in chronic infection. Clinical evidence indicates that function...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-316644
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we pro...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-316844
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of the most severe forms of the chronic viral hepatitis. However, there is a scarcity of data on the global burden of HDV infection. DESIGN...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316601
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in bone marrow (BM)-derived macrophages but its function in liver injury is unknown. Here we hypothesised that the anti-infl...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314107
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:Opioids are increasingly prescribed in the West and have deleterious GI consequences. Pharmacological therapies to treat opioid-induced constipation (OIC) are available, but their relative efficacy is unclear. We performed a systematic review and network meta-analysis to address this deficit in current knowle...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316001
更新日期:2019-03-01 00:00:00
abstract:CLINICAL PRESENTATION:A 28-year-old woman presented with a 3-year history of chronic watery diarrhoea along with abdominal pain and bloating, which could mostly be alleviated after defecation. Her symptom of diarrhoea, at least three times a day, could be relieved by neither probiotics nor antidiarrhoeal agents. She ha...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-316182
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers. METHOD:The Delphi method was used to develop consensus statements through identification of clinical ques...
journal_title:Gut
pub_type: 共识发展会议,杂志文章
doi:10.1136/gutjnl-2018-317111
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. DESIGN:We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expres...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314983
更新日期:2019-01-01 00:00:00
abstract::CLINICAL PRESENTATION: A 51-year-old man, who had no previous disease, underwent a screening oesophagogastroduodenoscopy, which revealed multiple yellowish lesions in the middle thoracic oesophagus. All lesions were ≤3 mm in size and slightly elevated. Each lesion showed one or two white protrusions on the surface (fi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315700
更新日期:2019-01-01 00:00:00
abstract::Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microb...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2017-315542
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The long-term performance of colorectal cancer (CRC) screening programmes based on a 2-year faecal immunochemical test (FIT) is still unclear. METHODS:In a sample of 50 to 69-year-olds repeatedly screened with the FIT (OC-Hemodia latex agglutination test; cut-off: 20 µg haemoglobin/g faeces), we examined: (...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314753
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To investigate the success rate of cold snare polypectomy (CSP) for complete resection of 4-9 mm colorectal adenomatous polyps compared with that of hot snare polypectomy (HSP). DESIGN:A prospective, multicentre, randomised controlled, parallel, non-inferiority trial conducted in 12 Japanese endoscopy units....
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2017-314215
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Extrahepatic manifestations of HCV are responsible for morbidity and mortality in many chronically infected patients. New, interferon-free antiviral treatment regimens, which present the opportunity to treat all HCV-infected patients, call for a better understanding of the benefits of treating non-c...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316234
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing the rate-limiting step of the NAD salvage pathway. NAMPT is strongly upregulated i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314241
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule (MAdCAM) to selectively reduce lymphocyte homing to the intestinal tract, i...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2016-313457
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment domain 9 (CARD9), a key innate immunity gene, is required to shape a normal gut microbiota. Card9-/- mice are more susceptible to the enteric mouse pathogen C...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314195
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315201
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct cancers in terms of a number of clinical and epidemiological characteristics, complicating the design of clinical trials and biomarker developments. We analysed 1048 oesophageal tumour-germline pairs from both subtypes, to chara...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314607
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Hippo signalling is a recently identified major oncosuppressive pathway that plays critical roles in inhibiting hepatocyte proliferation, survival and hepatocellular carcinoma (HCC) formation. Hippo kinase (Mst1 and Mst2) inhibits HCC proliferation by suppressing Yap/Taz transcription activities. As human HCC...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314061
更新日期:2018-09-01 00:00:00
abstract::Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis can culminate over time in an end-stage biliary cirrhosis. Both genetic and environmental influences are...
journal_title:Gut
pub_type: 指南,杂志文章,实务指引
doi:10.1136/gutjnl-2017-315259
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Metabolic reprogramming of tumour cells that allows for adaptation to their local environment is a hallmark of cancer. Interestingly, obesity-driven and non-alcoholic steatohepatitis (NASH)-driven hepatocellular carcinoma (HCC) mouse models commonly exhibit strong steatosis in tumour cells as seen in human st...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315193
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:A high body mass index (BMI) is associated with an increased risk for severe liver disease. It is unclear if this risk differs across BMI categories, and if the association is partially attributed to development of type 2 diabetes mellitus (T2DM). DESIGN:We used register data from more than 1.2 million Swedi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-313622
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312888
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:The response of subjects to preventive intervention is heterogeneous. The goal of this study was to determine if the efficacy of a chemopreventive agent differs in non-tumour-bearing animals versus those with colorectal tumours. Sulindac and/or atorvastatin was administered to Apc+/Min-FCCC mice with known tu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-313942
更新日期:2018-07-01 00:00:00